Abstract：Living matter relies on the self organization of its components into higher order structures, on the molecular as well as on the cellular, organ or even organism scale. Collective motion due to active transport processes has been shown to be a promising route for attributing fascinating order formation processes on these different length scales. Here I will present recent results on structure formation in organoid systems, demonstrating how mechanical feedback between extracellular matrix, proliferation and cell migration drives structure formation process in these multicellular model systems. I will present results on the developmental phase of mammary gland and pancreatic ducal adenocarcinoma organoids.

Bio：Prof. Bausch holds currently the Chair of Cellular Biophysics and is the Founding Director of the Center of Protein Assemblies at the Technical University of Munich. Since 2022 he is founding director of the Center of Organoid Systems and Tissue Engineering at the TUM. After studying physics at TUM and the Université de Montréal, he received his doctorate at TUM (1999). An Emmy Noether scholarship enabled him to study at Harvard University under Prof. D. Weitz. After receiving many invitations from around the world, Prof. Bausch accepted the Chair of Cellular Biophysics at TUM in 2008. He had a visiting Miller Professor Appointment at the University of California, Berkeley (2015) and since 2021 he is a visiting Scholar at Harvard University. His work targets a quantitative understanding of the mechanical properties of the cytoskeleton, and the microscopic mechanisms of self-organization on the molecular as well on the organoid scale, to which end he developed a range of active matter systems.