2023年5月5日下午，新加坡国立大学严洁教授在厦门大学物理科学与技术学院“萨本栋讲坛”作了题为Deciphering the Biophysical Principles Governing Cellular Mechanosensing and Mechanotransduction的学术报告。该讲座由物理科学与技术学院院长助理贺达海教授主持。

严洁教授报告现场

严洁教授从介绍细胞的机械力感知和机械力转导引出一系列相关的生物物理学原理在纯粹的物理学中融入生物的特点出发，开启了与会师生对于学科交叉、观念争鸣的探索之路。细胞中的机械感应涉及各种张力传递超分子连接的动态组装，每个连接是由几个非共价连接的蛋白质组成。细胞的机械力感知依赖于感知通过这些力传递超分子键传递的动态拉力。蛋白质结构域和蛋白质-蛋白质界面经历拉力的波动，导致超分子连接的高度动态的依赖力的连接，结构域的构象变化，以及细胞质内连接和信号蛋白中的受力蛋白之间的相互作用。此外，严洁教授还介绍了机械感应失调与各种疾病的关联，并分享了其团队在单分子技术与药物应用等方面的探索。

严洁教授报告现场

讲座报告期间，在场的师生积极参与交流讨论，就报告中提及的单分子等方面的潜在应用与严洁教授展开讨论。

主讲人简介：

Dr. Yan Jie is a single-molecule biophysicist who earned his PhD from the University of Illinois at Chicago in 2005. He currently holds the position of Full Professor in the Department of Physics and serves as a Principal Investigator at the Mechanobiology Institute at the National University of Singapore. There, he spearheads research in single-molecule studies, focusing on the micromechanics of DNA and proteins. His primary objective is to unravel the ways in which force-bearing proteins within cells can detect and react to mechanical forces and how these proteins can be targeted pharmaceutically. Dr. Yan's contributions to the field have been widely acknowledged; he has been elected as a Fellow of the American Physical Society and a Singapore NRF Investigator. Additionally, he has published over 130 papers and secured two patents.